Reductive decyanization of. alpha.-amino nitriles by borane

K Ogura, Y Shimamura, M Fujita

Index: Ogura, Katsuyuki; Shimamura, Yoshikazu; Fujita, Makoto Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2920 - 2922

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Citation Number: 14

Abstract

OPerformed in THF at room temperature.* Trans isomers.'Trans: cis= M20. dTrans: cis= 7822.'Compounds lg and lh are diastereomers.'Silica gel, elution with benzene/ethyl acetate (101)). 8Erythro: threo= 11.89.* Erythro: threo= 3565. amines from a-amino nitriles is also possible because the cyano group can be reductively removed. For example, sodium metal was effective for such a reduction, although the reaction conditions were drastic? It was ...

~96%

~96%

~70%

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