The objective of this work is the synthesis of diamagnetic close structural analogues of the more important doxyl 4, proxy1 5, piperidine 6, and pyrrolidine 7 nitroxide spin labels which are extensively used in biophysical investigations. Our approach is based on the observation that a nitroxide group is similar both in size and polarity to a carbonyl group of a ketone. Diamagnetic doxyl nitroxide analogues 11, 12, and 13 were prepared by a series ...
