Safe and Efficient Tetrazole Synthesis in a Continuous??Flow Microreactor

PB Palde, TF Jamison

Index: Palde, Prakash B.; Jamison, Timothy F. Angewandte Chemie - International Edition, 2011 , vol. 50, # 15 p. 3525 - 3528

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Citation Number: 74

Abstract

Tetrazoles are an important class of heterocycles in a wide range of applications, such as, organocatalysis and transitionmetal catalysis, propellants, explosives, and perhaps most commonly, as non-classical isosteres of carboxylic acids in medicinal chemistry.[1, 2] This broad utility has prompted significant effort toward tetrazole synthesis,[3] and notable among these is that of Sharpless, in which aqueous zinc bromide (ZnBr2) facilitates the assembly ...