Organometallics

Arene–Ruthenium (II) Complexes Containing Inexpensive Tris (dimethylamino) phosphine: Highly Efficient Catalysts for the Selective Hydration of Nitriles into Amides

R García-Álvarez, J Díez, P Crochet…

Index: Garcia-Alvarez, Rocio; Diez, Josefina; Crochet, Pascale; Cadierno, Victorio Organometallics, 2011 , vol. 30, # 20 p. 5442 - 5451

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Citation Number: 45

Abstract

The catalytic hydration of nitriles into amides, in water under neutral conditions, has been studied using a series of arene–ruthenium (II) derivatives containing the commercially available and inexpensive ligand tris (dimethylamino) phosphine. Among them, best results were obtained with the complex [RuCl2 (η6-C6Me6){P (NMe2) 3}], which selectively provided the desired amides in excellent yields and short times (TOF values up to 11 400 ...