Tetrahedron letters

Synthesis of 6-phosphonoalkyl tetrahydro-4-pyrimidine-carboxylic acids as NMDA receptor antagonists

CF Bigge, JP Wu, JR Drummond

Index: Bigge, Christopher F.; Wu, Jiang-Ping; Drummond, James R. Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7659 - 7662

Full Text: HTML

Citation Number: 5

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The title compounds were prepared via a sequence which involved as the key steps a Michael reaction between nitroakyl phosphonates and protected dehydroalanine and subsequent cyclization of the α,γ-diamino esters. ... Parke-Davis Pharmaceutical Research Division, Warner- ...