Abstract Synthesis of 2-normisoprostol, methyl 6-(3-hydroxy-2-((E)-4-hydroxy-4-methyloct-1- enyl)-5-oxocyclopentyl) hexanoate (3), employing two-component coupling strategy based on 1, 4-addition followed by DDQ-mediated triethyl silyl deprotection is reported. Desired key intermediates, methyl 6-(3-triethyl silyloxy-5-oxocyclopent-1-enyl) hexanoate (4) and (E)- 1-(tributylstannyl)-4-methyloct-1-en-4-yloxy) triethylsilane (5), were prepared from ...
