Journal of heterocyclic chemistry

Heterocycles of biological importance. Part 2. Novel synthesis and pharmacological evaluation of 5??amino??3??alkyl??1??(2??pyridyl) pyrazoles and 5??amino??3??phenyl??1?? …

ZT Fomum, PN Ifeadike

Index: Fomum, Tanee Z.; Ifeadike, Ngozi P. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1611 - 1614

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Citation Number: 11

Abstract

Abstract 2-Hydrazinopyridine reacts with allenic and acetylenic nitriles to give 5-amino-3- alkyl-1-(2-pyridyl) pyrazoles 6 in excellent yields. One of these compounds, 6e has been shown to possess anticonvulsant and anti-electroshock properties. Phenyl propynenitrile also reacts with hydrazinopyridine to give 5-amino-3-phenyl-1-(2-pyridyl) pyrazole (11) in quantitative yield.