Chemical Communications

Highly enantioselective intramolecular aza-spiroannulation onto indoles using chiral rhodium catalysis: asymmetric entry to the spiro-β-lactam core of chartellines

S Sato, M Shibuya, N Kanoh, Y Iwabuchi

Index: Sato, Shigeki; Shibuya, Masatoshi; Kanoh, Naoki; Iwabuchi, Yoshiharu Chemical Communications, 2009 , # 41 p. 6264 - 6266

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Citation Number: 23

Abstract

Bryozoans living in the marine environment inspire the synthetic community by presenting secondary metabolites with exquisitely complicated architectures. Chartellines (1a–c, Fig. 1), 1 the small group of unique, indole–imidazole alkaloids isolated from Chartella papyracea have received considerable attention as targets for total synthesis, 2–5 regardless of there being no reports to suggest their pharmaceutical applicability. Synthetic routes to the chartellines have yet ...