Influence of enantiomers of 1-naphthylalanine in position 2 of VAVP and dVAVP on their pharmacological properties

I Derdowska, A Prahl, W Kowalczyk, M Janecki…

Index: Derdowska, Izabela; Prahl, Adam; Kowalczyk, Wioleta; Janecki, Marcin; Melhem, Samed; Trzeciak, Henryk I.; Lammek, Bernard European Journal of Medicinal Chemistry, 2005 , vol. 40, # 1 p. 63 - 68

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Citation Number: 12

Abstract

In this study, we described the synthesis and some pharmacological properties of four new analogues of arginine vasopressin (AVP). Two peptides are substituted in position 2 with l-1- naphthylalanine (l-1-Nal) or its d-enantiomer and in position 4 with valine. In the further two compounds, we combined the above modifications with placement into position 1 of 3- mercaptopropionic acid residue (Mpa). All new peptides were tested for vasopressor and ...