Inhibition of serine and proline racemases by substrate-product analogues

…, M Nagar, L Atkinson, CM LeGay, DJ Derksen…

Index: Harty, Matthew; Nagar, Mitesh; Atkinson, Logan; Legay, Christina M.; Derksen, Darren J.; Bearne, Stephen L. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 390 - 393

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Citation Number: 6

Abstract

Abstract d-Amino acids can play important roles as specific biosynthetic building blocks required by organisms or act as regulatory molecules. Consequently, amino acid racemases that catalyze the formation of d-amino acids are potential therapeutic targets. Serine racemase catalyzes the reversible formation of d-serine (a modulator of neurotransmission) from l-serine, while proline racemase (an essential enzymatic and mitogenic protein in ...