The synthesis, antibacterial activity, and stability to human dehydropeptidase-1 (DHP-1) of a novel series of (5R, 6S)-6-[(1R)-1-hydroxyethyl]-2-heterocyclylcarbapen-2-em-3- carboxylates are described. Of the compounds investigated 1, 5-disubstituted pyrazol-3-yl and 3-substituted isoxazol-5-yl derivatives have the best combination of antibacterial activity and stability to DHP-1. They are particularly active against community-acquired respiratory ...
