Arkivoc

Iodine-mediated one-pot synthesis of indoles and 3-dimethylaminoindoles via annulation of enaminones

…, EM Labarrios, FE Jiménez, M del Carmen Cruz…

Index: Jerezano, Alberto V.; Labarrios, Ehecatl M.; Jimenez, Fabiola E.; Del Cruz, Maria Carmen; Pazos, Diana C.; Gutierrez, Rsuini U.; Delgado, Francisco; Tamariz, Joaquin Arkivoc, 2013 , vol. 2014, # 3 p. 18 - 53

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Citation Number: 1

Abstract

Abstract The synthesis of 2-carbonylindoles was achieved via a iodine-mediated cyclization of the corresponding enaminone precursors, which were formed by reaction of the α- arylaminomethylene carbonyl derivatives with N, N'-dimethylformamide dimethyl acetal (DMFDMA). An alternative and more efficient procedure consisted of a similar cyclization of the enaminones, but under solvent-free and grinding reaction conditions. In another ...