Abstract A series of 5, 6, 7-trimethoxy-N-phenyl (ethyl)-4-aminoquinazoline compounds was prepared by microwave irradiation and conventional heating methods. Compounds 6p, 6q, and 6x strongly inhibited extracellular regulated kinase1/2 (ERK1/2) phosphorylation induced by epidermal growth factor (EGF) at 1.28 μM in PC3 cells. 3-(4, 5-Dimethylthiazol-2- yl)-2, 5-diphenyltetrazolium bromide assay showed that all compounds had certain ...
