A short enzymatic route for the synthesis of L-fucose analogs isomerase (FucI) from E. coli. Enantiomerically pure L-fucose analogs have been prepared in up to 30% overall yield modified at the nonpolar terminus is reported. In particular, fucose derivatives bearing extended linear (1b) and starting from the appropriate hydroxyaldehyde precursors and dihydroxyacetone phosphate as readily available branched (1e) saturated, or various ...
