Chiral Phosphoric Acid Catalyzed Enantioselective Transfer Hydrogenation of ortho??Hydroxybenzophenone N H Ketimines and Applications

TB Nguyen, Q Wang, F Guéritte

Index: Nguyen, Thanh Binh; Wang, Qian; Gueritte, Franioise Chemistry - A European Journal, 2011 , vol. 17, # 35 p. 9576 - 9580

Full Text: HTML

Citation Number: 26

Abstract

Enantiomerically pure diarylmethylamines are important substructures found in a variety of biologically active compounds.[1, 2d] They are generally obtained by the chiral auxiliary or chiral ligand-based Rh-catalyzed addition of organometallic reagents to imines.[2–4] Although many highly enantioselective hydrogenations of various imines are known,[5, 6] the enantioselective reduction of substituted benzophenone imines has been rarely ...