Synthesis

A Convenient method for the preparation of primary and symmetrical N, N′-disubstituted thioureas

RJ Herr, JL Kuhler, H Meckler, CJ Opalka

Index: Herr; Kuhler; Meckler; Opalka Synthesis, 2000 , # 11 p. 1569 - 1574

Full Text: HTML

Citation Number: 24

Abstract

Abstract: A convenient process for the preparation of both primary thioureas 2 and symmetrical N, N'-disubstituted thioureas 6 based on the condensation of amine hydrohalides 5 with potassium thiocyanate has been developed. This approach tolerates sterically bulky primary amine substrates (both chiral and achiral), and the products can usually be isolated by a simple filtration of the reaction mixture. This method is an ...