Derivatisation of an Anti??Cancer Cationic Antimicrobial Peptide and its Complexation to Platinum (II)

…, M Devocelle, CJ Marmion

Index: Parker, James P.; Devocelle, Marc; Marmion, Celine J. Zeitschrift fur Anorganische und Allgemeine Chemie, 2013 , vol. 639, # 8-9 p. 1628 - 1635

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Citation Number: 3

Abstract

Abstract This work focuses on the cationic antimicrobial peptide (CAP) DP18L with its known propensity to target and selectively kill cancer cells. DP18L was derivatised to dap-DP18L where dap is 2, 3-diaminopropionic acid. Dap facilitated binding to Pt II via an (N, N') bidentate ligand to afford the first reported Pt-CAP complex, cis-[Pt (dap-DP18L) Cl 2)]. The syntheses of the peptides and the Pt-peptide complex were carried out using solid phase ...