Cobalt-catalyzed regioselective carbocyclization reaction of o-iodophenyl ketones and aldehydes with alkynes, acrylates, and acrylonitrile: A facile route to indenols …

KJ Chang, DK Rayabarapu…

Index: Chang, Kuo-Jui; Rayabarapu, Dinesh Kumar; Cheng, Chien-Hong Journal of Organic Chemistry, 2004 , vol. 69, # 14 p. 4781 - 4787

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Citation Number: 86

Abstract

An efficient cobalt-catalyzed carbocylization for the synthesis of indenols and indenes and a new method for reductive decyanation are described. 2-Iodophenyl ketones and aldehydes 1a-g undergo carbocyclization with various disubstituted alkynes 2a-k in the presence of Co (dppe) I2 and zinc powder in acetonitrile at 80° C for 3 h to afford the corresponding indenol derivatives 3a-s and 4a-m in good to excellent yields. For some unsymmetrical alkynes, ...