Abstract A very useful synthesis of (3S)-2, 3-oxidosqualene from geraniol, farnesol and E-1- bromo-4-chloro-3-methyl-2-butene is described which makes use of enantioselective and catalytic dihydroxylation of geranyl acetate and two E-stereospecific allylic coupling reactions mediated by E-prenylbarium reagents.
