A Rapid and Efficient Approach to Chiral, Nonracemic Aza Sugars from Nonsugars. A Formal Synthesis of 1, 4-Dideoxy-1, 4-imino-d-lyxitol

…, JE Resek, MA McLaughlin, CC Woodall…

Index: Meyers; Andres; Resek, James E.; McLaughlin, Maureen A.; Woodall, Charlotte C.; Lee Journal of Organic Chemistry, 1996 , vol. 61, # 8 p. 2586 - 2587

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Citation Number: 27

Abstract

Azasugars 1 and 2 are particularly attractive synthetic targets because of their important biological properties which include glycosidase inhibition, 1 tumor growth inhibition, 2 and anti-HIV3 behavior. The recent intense activity targeting the synthesis of azasugars has produced a large number of elegant and efficient routes based on carbohydrate4 and noncarbohydrate5 starting materials. Most of these routes, however, suffer from excessive ...