Determination of 3JHF and 4JHF Karplus relationships for the. vphi. and. psi. angles of peptides using N-fluoroamides as models

CF Hammer, S Chandrasegaran

Index: Hammer, Charles F.; Chandrasegaran, Srinivasan Journal of the American Chemical Society, 1984 , vol. 106, # 6 p. 1543 - 1552

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Citation Number: 15

Abstract

Abstract: A series of N-fluoroamide derivatives were synthesized by the reaction of CF30F with the corresponding amides. The reaction procedure of Barton et a1. l was appropriately modified to maximize the yield of the pure monofluoro derivatives. The compounds were examined as models for the determination of the 4 '(, &F) and I)'(4J~~) angles of peptides with 'H, I9F, and I3C NMR spectroscopy. Investigation of this series of compounds has led ...