Novel antagonists of the 5-HT3 receptor. Synthesis and structure-activity relationships of (2-alkoxybenzoyl) ureas

G Bradley, TJ Ward, JC White, J Coleman…

Index: Bradley; Ward; White; Coleman; Taylor; Rhodes Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1515 - 1520

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Citation Number: 20

Abstract

3; 5-C1; I1 0-2-Me0 I NH-4-Me0 I NH-2-Me I NH-2-FI NH-2-Me0 I 0-2, 6-Me0 I NH-2-Me0@)- I8 NH-2-Me0(&Ih NH-2-Me0 I1 NH 2 2-Me0 exo-I1 NH 2 2-Me0 I1 NH 3 2-Me0, 5-C1 I1 NH 2 2-Me0, 4-N02 I1 NH 2 2-Me0, 4-NH2 I1 NH 2 2-Me0, 4-NHz, 5-C1 I1 NH 2 2-Et0 I1 NH 2 2-n- Pro I1 NH 2 2-n-BuO I1 NH 2 2-n-pentyl0 I1 NH 2 2-c-PrCH20 I1 NH 2 2-iP r 0 I1 NH 2 2-i- PrCH20 I1 NH 2 2-i-PrCH2CH20 I1 NH 2 2-HO I1 NH 2 2-Me0 I1 0 2 ondansetron zacopride