Synlett

An efficient new synthesis of racemic cetiedil and a novel route to α-ketocarboxylic acids utilising mild conditions

CJ Roxburgh, CR Ganellin, AJ Thorpe

Index: Roxburgh, Craig J.; Ganellin, C. Robin; Thorpe, Andrew J. Synlett, 2007 , # 8 p. 1211 - 1214

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Abstract

Abstract We describe a new efficient synthesis of the prescribed racemic drug cetiedil [(±)-2- cyclohexyl-2-(3-thienyl) ethanoic acid 2-(hexahydro-1H-azepin-1-yl) ethylester]. Additionally, we report herein a high yielding large scale, route to its acid precursor 7, subsequently enabling large-scale synthesis of the chiral forms of cetiedil, and detailed pharmacological investigations.