Synthesis

The Diels-Alder approach for the synthesis of tetralin-based α-amino acid derivatives and their modification by the Suzuki-Miyaura cross-coupling reaction

S Kotha, AK Ghosh

Index: Kotha, Sambasivarao; Ghosh, Arun Kumar Synthesis, 2004 , # 4 p. 558 - 567

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Citation Number: 15

Abstract

Abstract Tetralin-based α-amino acid (AAA) is a constrained analogue of phenylalanine (Phe) and is used extensively in the design and synthesis of a variety of bioactive peptides. Due to the nonavailability of simple synthetic methods to deliver complex cyclic AAAs, only simplest members of this class have been used in the peptide area. In this regard, we have developed a new method to prepare various highly functionalized tetralin-based unusual ...