Abstract Starting from appropriately halogenated acylpyrroles, a wide range of reactive 4, 4- difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) derivatives can be obtained. The fluorescent dyes display excellent reactivity in nucleophilic aromatic substitution, transition- metal-catalyzed cross-coupling and copper-catalyzed cycloaddition to azides (click chemistry). The spectral properties of the starting and final difluoroboron dipyrromethenes ...