Synthesis and evaluation of β-carboline derivatives as inhibitors of human immunodeficiency virus

KG Brahmbhatt, N Ahmed, S Sabde, D Mitra…

Index: Brahmbhatt, Keyur G.; Ahmed, Nafees; Sabde, Sudeep; Mitra, Debashis; Singh, Inder Pal; Bhutani, Kamlesh K. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4416 - 4419

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Citation Number: 36

Abstract

A series of β-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL4. 3 virus. 1-Formyl-β-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC50= 2.9 μM.

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