Russian journal of organic chemistry

Synthesis of Methyl-N-[4-(3-R-amino-2-hydroxypropoxy) phenyl] carbamates

AV Velikorodov

Index: Velikorodov Russian Journal of Organic Chemistry, 2004 , vol. 40, # 2 p. 188 - 190

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Citation Number: 3

Abstract

Abstract By alkylation of methyl-N-(4-hydroxyphenyl) carbamate with (chloromethyl) oxirane in acetone in the presence of K 2 CO 3 methyl-N-[4-(2, 3-epoxypropoxy) phenyl] carbamate was prepared. The aminolysis of the latter effected by benzylamine, morpholine, piperidine, and pyrrolidine occurs in keeping with Krasusky rule to afford methyl-N-[4-(3-R-amino-2- hydroxypropoxy) phenyl] carbamates.