Regioselectivity of the reactions of 4, 5??diphenylimidazole??2??thione with 1??chloro??2, 3??epoxy??propane and 1??bromo??propene, efficient precursors for imidazo [2, 1??b] …

M Aouad, NT Rezki, ESH El Ahsry

Index: Aouad, Mohamed R.; Rezki, Nadjet; El Ahsry, El Sayed H. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 5 p. 1321 - 1327

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Citation Number: 6

Abstract

The imidazole core is a common moiety in a large number of natural products and pharmacologically active compounds [1]. Moreover, valuable biological applications such as antifungal [2], anti-thyroid [3] and antiasthmatic [4] activities have been associated with 2- thiosubstituted imidazoles. Its annulations with a thiazine or thiazole ring provide imidazo- thiazines and thiazoles with a wide spectrum of biological and pharmacological properties ...

~90%

Acyl-CoA: cholesterol O-acyl transferase (ACAT) inhibitors. ...

[Harris, Neil V.; Smith, Christopher; Asthon, Michael J.; Bridge, Andrew W.; Bush, Raymond C.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4384 - 4392]

Synthesis and Metabolic Studies of Host-Directed Inhibitors ...

[Moore, Terry W.; Sana, Kasinath; Yan, Dan; Krumm, Stefanie A.; Thepchatri, Pahk; Snyder, James P.; Marengo, Jose; Arrendale, Richard F.; Prussia, Andrew J.; Natchus, Michael G.; Liotta, Dennis C.; Plemper, Richard K.; Sun, Aiming ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 8 p. 762 - 767]