Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and …

M Cushman, D Yang, S Gerhardt, R Huber…

Index: Wrigglesworth, Roger; Inglis, W. David; Livingstone, Daniel B.; Suckling, Colin J.; Wood, Hamish C. S. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 5 p. 959 - 963

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Citation Number: 38

Abstract

... J. Org. ... Deprotection of the phosphate by hydrogenolysis over palladium hydroxide on carbon afforded the expected phosphate 32, which was reacted with the lumazine ... a Reagents and conditions: (a) NaOEt, EtOH, diethyl oxalate, 0 °C (1 h); (b) HBr, AcOH, 120 °C (4 h); (c ...