Synthesis and antimicrobial activities of halogenated bis (hydroxyphenyl) methanes

…, JH Lee, JW Lee, KM Yoon, SC Chung, HB Jeon…

Index: Oh, Ki-Bong; Lee, Ji Hye; Lee, Jong Wook; Yoon, Kyung-Mi; Chung, Soon-Chun; Jeon, Heung Bae; Shin, Jongheon; Lee, Hyi-Seung Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 945 - 948

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Citation Number: 25

Abstract

A series of halophenols was prepared by the reaction of bis (hydroxyphenyl) methanes with effective halogenating agents such as bromine and sulfuryl chloride. One of these compounds, a biologically active halophenol—2, 2′, 3, 3′-tetrabromo-4, 4′, 5, 5′- tetrahydroxydiphenylmethane (1)—frequently isolated from red algae, was synthesized for the first time. Other halophenols included several novel compounds, together with known ...