Identification of a novel series of selective 5-HT 7 receptor antagonists

…, M Meeson, LP Campbell, T Coleman, GJ Riley…

Index: Forbes, Ian T.; Cooper, David G.; Dodds, Emma K.; Douglas, Sara E.; Gribble, Andrew D.; Ife, Robert J.; Lightfoot, Andrew P.; Meeson, Malcolm; Campbell, Lorraine P.; Coleman, Tanya; Riley, Graham J.; Thomas, David R. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1055 - 1058

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Citation Number: 34

Abstract

Novel 5-HT7 receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Molecular modelling and SAR studies have converted these intractable hits into a more potent, selective and tractable series, exemplified by ...