'Halex'fluorination of chlorinated benzaldehydes and benzoyl chlorides

RE Banks, KN Mothersdale, AE Tipping…

Index: Banks, R. Eric; Mothersdale, Kevin N.; Tipping, Anthony E.; Tsiliopoulos, Efthimios; Cozens, Barry J.; et al. Journal of Fluorine Chemistry, 1990 , vol. 46, # 3 p. 529 - 537

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Citation Number: 5

Abstract

Spray-dried potassium fluoride, suspended in sulpholane at 220 °C, converted 2,4- and 2,6-dichlorobenzaldehyde into the corresponding difluoroaldehydes (yields . 65%). Small amounts of the mono-substituted products (2-chloro-4-fluoro- + 4-chloro-2-fluoro-benzaldehyde, and 2-chloro-6-fluoro-benzaldehyde , respectively) were also produced. Similar treatment of the 3,4-dichloro-analogue gave 3-chloro-4-fluorobenzaldehyde (yield 98%, conversion 68%), but 2- and 4- ...