Iron-Catalyzed Direct Arylation through Directed C− H Bond Activation

…, A Matsumoto, N Yoshikai, E Nakamura

Index: Norinder, Jakob; Matsumoto, Arimasa; Yoshikai, Naohiko; Nakamura, Eiichi Journal of the American Chemical Society, 2008 , vol. 130, # 18 p. 5858 - 5859

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Citation Number: 251

Abstract

An iron-catalyzed C− C bond formation reaction of a nitrogen-containing aromatic compound with an arylzinc reagent takes place at 0° C in a good to quantitative yield. The reaction involves a C− H bond activation directed by a neighboring nitrogen atom. The important additives in this reaction are 1, 10-phenanthroline, tetramethylethylenediamine, and 1, 2-dichloro-2-methylpropane, in the absence of which a very low product yield was ...