Angewandte Chemie International Edition

Total Synthesis of RNA??Polymerase Inhibitor Ripostatin B and 15??Deoxyripostatin A

W Tang, EV Prusov

Index: Tang, Wufeng; Prusov, Evgeny V. Angewandte Chemie - International Edition, 2012 , vol. 51, # 14 p. 3401 - 3404

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Citation Number: 23

Abstract

Natural products isolated from marine and terrestrial microorganisms, plants, and fungi play a crucial role in drug discovery and development in important areas, such as antibiotics research and cancer treatment.[1] The emergence of multi-drug-resistant strains over the past decades is a problem that plagues public health.[2] Consequently, the continuous search for new drug candidates that use a novel mode of action is essential for effective ...