Methyl 5-carboxamido-4-hydroxy-3 (β-D-ribofuranosyl)-2-thiophene carboxylate 2 a and the corresponding 2, 5-thiophene dicarboxamide 2 b, two new analogues of the antiviral compound pyrazofurin, were synthesized. A base mediated condensation method with dimethyl thiodiacetate and methyl 2 (2, 3, 5,-tri-Ot-butyldimethylsilyl-β-D-ribofuranosyl)-2- oxoacetate 5 was used. The structure of these compounds and their intermediates was ...
