Facile Total Syntheses of Idarubicinone??7?螃漫?D??glucuronide: Convenient Preparations of AB??Ring Synthon Using Some Carboxylic Acid Derivatives

YS Rho, J Park, G Kim, H Kim, H Sin…

Index: Rho, Young S.; Park, Jihyung; Kim, Gyuil; Kim, Hyesun; Sin, Hongsig; Suh, Pyoung Won; Yoo, Dong Jin Synthetic Communications, 2004 , vol. 34, # 9 p. 1703 - 1722

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Citation Number: 8

Abstract

Abstract Regiospecific syntheses of idarubicinone coupled with d??glucuronic acid are described. Cyclization of dimethoxybenzene with carboxylic acid derivatives in polyphosphoric acid (PPA) in one step afforded the naphthalenones 7, which were transformed to the (±)??idarubicinone 3b by general methods. Esterification of (±)??3b with (S)?? (+)??O??acetylmandelic acid with subsequent separation and deprotection gave (+)??3b and ...