Synthesis and biological study of some new naphtho [2, 1-b] furan and related heterocyclic systems

MZA Badr, AMK El-Dean, OS Moustafa…

Index: Badr, Mahmoud Z. A.; El-Dean, Adel M. Kamal; Moustafa, Osama S.; Zaki, Remon M. Journal of Chemical Research, 2006 , # 11 p. 748 - 752

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Citation Number: 5

Abstract

In the reaction of 1-cyano-2-naphthol (4) or its sodium salt with different alkylating agent, the O-alkylated derivatives (5a-d) were produced which underwent ring closure reactions using sodium ethoxide solution to give aminonaphtho [2, 1-b] furan derivatives (6a-d). Ethyl 3- aminonaphtho [2, 1-b] furan-2-carboxylate (8) was reacted with formamide to afford naphtho [1 ', 2 ': 4, 5] furo [3, 2-d] pyrimidine (11) derivatives. The produced pyrimidino compound ...