Abstract An efficient asymmetric synthesis of (S)-2, 3-dihydrobenzo [b] furan-3-carboxylic acid (8 a) and (S)-5-chloro-2, 3-dihydrobenzo [b] furan-3-carboxylic acid (8 b) was established. Key to the success was the highly stereoselective enzymatic kinetic resolution of the corresponding methyl or ethyl esters that was further developed into a dynamic process. As a reliable and fast tool for analysing the enantiomeric excess, HPLC coupled ...
