Pyrimidine derivatives. V. Synthesis and nucleophilic reactions of 5-bromo-6-bromomethyl-1-(2-bromoethyl and 2-bromopropyl)-3-methyl-2, 4 (1H, 3H)- …

T KINOSHITA, N NAKAHATA, A KOUCHI…

Index: Kinoshita, Toshio; Nakahata, Noriko; Kouchi, Akiko; Furukawa, Sunao Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 10 p. 3887 - 3896

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Citation Number: 8

Abstract

The reaction of 1-(2-hydroxyethyl and 2-hydroxypropy1)-3, 6-dimethyl-2, 4 (1H, 3H)- pyrimidinedione (2 and 3) with bromine afforded 5-bromo-6-bromomethyl-l-(2-bromoethyl and 2-bromopropy1)-(4 and 5), 5-bromo-1-(2-bromoethyl)-6-dibromomethy1-2, 4 (1H, 3H)- pyrimidinedione (6), and 8, 8-dibromo-6, 8a-dimethyl (or 2, 6, 8a-trimethyl)-5, 7- dioxoperhydrooxazolo [3, 2-c] pyrimidine (8 or 9). Compound 4 reacted with sodium ...