Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5, 9-dihydro-3 H, 4 H-2, 6-dioxa-4-azacyclopenta [b] naphthalene-1, 8-dione, a Dihydropyridine ATP-Sensitive …

…, M Gopalakrishnan, RF Henry, A Khilevich…

Index: Altenbach, Robert J.; Brune, Michael E.; Buckner, Steven A.; Coghlan, Michael J.; Daza, Anthony V.; Fabiyi, Adebola; Gopalakrishnan, Murali; Henry, Rodger F.; Khilevich, Albert; Kort, Michael E.; Milicic, Ivan; Scott, Victoria E.; Smith, Jamie C.; Whiteaker, Kristi L.; Carroll, William A. Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6869 - 6887

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Citation Number: 19

Abstract

Structure-activity relationships were investigated on the tricyclic dihydropyridine (DHP) KATP openers 9-(3-bromo-4-fluorophenyl)-5, 9-dihydro-3 H, 4 H-2, 6-dioxa-4-azacyclopenta [b] naphthalene-1, 8-dione (6) and 10-(3-bromo-4-fluorophenyl)-9, 10-dihydro-1 H, 8 H-2, 7- dioxa-9-azaanthracene-4, 5-dione (65). Substitution off the core of the DHP, absolute stereochemistry, and aromatic substitution were evaluated for KATP channel activity using ...