Journal of Fluorine Chemistry

The use of methyl 2, 2-difluoro-2-(fluorosulfonyl) acetate as the difluorocarbene source to generate an in situ source of difluoromethylene triphenylphosphonium ylide

CS Thomoson, H Martinez, WR Dolbier

Index: Thomoson, Charles S.; Martinez, Henry; Dolbier Jr., William R. Journal of Fluorine Chemistry, 2013 , vol. 150, p. 53 - 59

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Citation Number: 26

Abstract

Under moderate conditions in the presence of a demethylating reagent, such as iodide, methyl 2, 2,-difluoro-2-(fluorosulfonyl) acetate (MDFA) releases difluorocarbene, which in the presence of triphenylphosphine forms difluoromethylene triphenylphosphonium ylide. ...

~77%

~75%

Detail

~5%

Detail

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~68%

~50%

Detail

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~29%

~40%

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