Biological Activity.--Antiinflammat, ory activity was measured by a rat paw edema test using yeast as irritant. l 2 In this assay, 2-(2, 6-xylyloxy) ethylguariidine (I, Table I, 1) was shown to have a pronounced activity and a dose of 100 mg./kg. p. 0. caused 50% inhibition of edema format'ion. As phenylbutazone and most other clinically eff ect'ive antiinflammatory drugs only show significant activity in this test at doses approaching the LDbo, 1 was used as a ...
