4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors

…, G Xu, J Kirkpatrick, H Ott, CA Baumann

Index: Gaul, Micheal D.; Xu, Guozhang; Kirkpatrick, Jennifer; Ott, Heidi; Baumann, Christian A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4861 - 4865

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Citation Number: 13

Abstract

A series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF3 expressed cell line. The structure–activity relationship of this class of compounds is described.