Synthesis and in vitro antifungal activities of novel triazole antifungal agent CS-758.

…, Y Nakamura, S SEKI, T UCHIDA, A SOMADA…

Index: Konosu, Toshiyuki; Oida, Sadao; Nakamura, Yoshie; Seki, Shinobu; Uchida, Takuya; Somada, Atsushi; Mori, Makoto; Harada, Yoshiko; Kamai, Yasuki; Harasaki, Tamako; Fukuoka, Takashi; Ohya, Satoshi; Yasuda, Hiroshi; Shibayama, Takahiro; Inoue, Shin-Ichi; Nakagawa, Akihiko; Seta, Yasuo Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1647 - 1650

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Citation Number: 14

Abstract

Synthesis and in vitro antifungal activities of a novel triazole antifungal agent CS-758 (former name, R-120758) are described. The minimum inhibitory concentrations (MICs) of a series of dioxane-triazole compounds related to R-102557 were examined. Variation of the length of the chain between the dioxane ring and the phenyl ring revealed that the linkage with two double bonds is the most preferable. When a cyano group was introduced to the C4 ...