Organic letters

Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway

…, X Wang, WC Brown, L Kuai, SL Schreiber

Index: Gray, B. Lawrence; Wang, Xiang; Brown, W. Colby; Kuai, Letian; Schreiber, Stuart L. Organic Letters, 2008 , vol. 10, # 13 p. 2621 - 2624

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Citation Number: 30

Abstract

Recognizing the value of including complex pyridines in small-molecule screening collections, we developed a previously unexplored [2+ 2+ 2]-cycloaddition of silyl-tethered diynes with nitriles. The tether provides high regioselectivity, while the solvent THF allows catalytic CpCo (CO) 2 to be used without exogenous irradiation. One of the resulting bicyclic and monocyclic (desilylated) pyridines was identified as an inhibitor of neuregulin- ...