The diicovery2 that 2-diethylaminoethyl 4-niethj 1-I) ii) erazine-l-carboxS. late (1) exhibit< significant anti-viral activity against an Influenza (PR8) infection in riiice led US to synthesize variou-arialogs and deriva-t ivei. Thih report de~~ ibes the structure-xtivity ielationships of thebe compounds ti9 n ell: is ioinc of the. rhcmiitrj involved in their iyntheies. a\ b\ c! d