Graphite brings about a rapid Mannich reaction with a range of activated and unactivated phenolic compounds such as p-cresol and p-nitrophenol. The reactions are carried out with azacrown ether and paraformaldehyde in solvent-free conditions at 100° C for 20-30 min. The graphite powder can be reused up to three times after simple washing with acetone. Key words: azacrown ether, lariat ether, graphite, solvent-free, Mannich reaction.
![2-[[bis(2-hydroxyethyl)amino]methyl]-4-methylphenol Structure](https://image.chemsrc.com/caspic/141/96182-90-0.png)