Synthesis of derivatives of piperidine and decahydroquinoline, and their analgesic and psychotropic properties

KD Praliev, NA Belikova, VM Kurilenko…

Index: Praliev, K. D.; Belikova, N. A.; Kurilenko, V. M.; Khlienko, Zh. N.; Moiseeva, L. M.; Sokolov, D. V. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 10 p. 697 - 702 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 10 p. 1203 - 1208

Full Text: HTML

Citation Number: 0

Abstract

Alkylation of I in acetone with propargyl bromide (IX) in the presence of anhydrous potassium carbonate at 70~ gave l-propargyl-4-phenylpiperidin-4-ol (X). Interaction of the latter with bromophenylacetylene (XI)[3] under Khodkevich--Kado reaction conditions [6] formed the diacetylenic alcohol (XII) in 76.2% yield.