6-Hydroxycinnolines 2 and cyclohexa-2, 5-diene-1, 4-dione derivatives 6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 6- Hydroxycinnolines 2 showed, in general, more potent antifungal activity against Candida species than the other cyclohexa-2, 5-diene-1, 4-diones. The results suggest that 6- hydroxycinnolines would be potent antifungal agents.
