Potent naphthoquinones against antimony-sensitive and-resistant Leishmania parasites: Synthesis of novel α-and nor-α-lapachone-based 1, 2, 3-triazoles by copper- …

TT Guimarães, FR Maria do Carmo, JS Lanza…

Index: Guimaraes, Tiago T.; Pinto, Maria Do Carmo F.R.; Lanza, Juliane S.; Melo, Maria N.; Do Monte-Neto, Rubens L.; De Melo, Isadora M.M.; Diogo, Emilay B.T.; Ferreira, Vitor F.; Camara, Celso A.; Valenca, Wagner O.; De Oliveira, Ronaldo N.; Frezard, Frederic; Da Silva Junior, Eufranio N. European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 523 - 530

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Citation Number: 36

Abstract

Continuing our screening program for novel anti-parasite compounds, we synthesized seven 1, 4-naphthoquinones coupled to 1, 2, 3-triazoles, five nor-β-lapachone-based 1, 2, 3- triazoles and ten α-lapachone-based 1, 2, 3-triazoles. These and other naphthoquinonoid compounds were evaluated for their activity against promastigote forms of antimony- sensitive and-resistant strains of Leishmania infantum (syn. Leishmania chagasi) and ...